{"studyId":"msk_met_2021","cancerTypeId":"mixed","name":"MSK MetTropism (MSK, Cell 2021)","description":"MSK-MET (Memorial Sloan Kettering - Metastatic Events and Tropisms) is a pan-cancer cohort of tumor genomic and clinical outcome data from 25,000 patients. The dataset identifies associations between tumor genomic alterations and patterns of metastatic dissemination across 50 tumor types; showing that chromosomal instability is strongly correlated with metastatic burden in some tumor types, like prostate and lung adenocarcinomas and HR+/HER2+ breast ductal carcinoma, but not in others, such as colorectal MSS, pancreatic adenocarcinoma and high-grade serous ovarian cancer. The study also identifies somatic alterations associated with increased metastatic burden and routes of metastatic spread. Our data offers a resource for the investigation of the biologic basis for metastatic spread and highlights the role of chromosomal instability in cancer progression. This data is available under the <a href=\"https://creativecommons.org/licenses/by-nc-nd/4.0/deed.en\">Creative Commons BY-NC-ND 4.0 license</a>.","publicStudy":true,"pmid":"35120664","citation":"Nguyen et al. Cell 2022","groups":"","status":1,"importDate":"2026-01-08 17:17:00","allSampleCount":25775,"sequencedSampleCount":25775,"cnaSampleCount":25775,"mrnaRnaSeqSampleCount":0,"mrnaRnaSeqV2SampleCount":0,"mrnaMicroarraySampleCount":0,"miRnaSampleCount":0,"methylationHm27SampleCount":0,"rppaSampleCount":0,"massSpectrometrySampleCount":0,"completeSampleCount":0,"referenceGenome":"hg19","treatmentCount":0,"structuralVariantCount":5410,"cancerType":{"id":"mixed","name":"Mixed Cancer Types","dedicatedColor":"Black","shortName":"MIXED","parent":"other"},"readPermission":true,"resourceCounts":[]}